Back in the first dewy shine of Amélie (2001), I would not have anticipated beginning a review with the words “Audrey Tautou is frankly too old to [fill in the blank].” But the years pass. And so: Audrey Tautou is too old to play the early scenes here as a teenage bride in 1920s France. Thankfully, the movie advances in time, and the still-youthful Tautou (she’s 37) very effectively brings her eerie presence to bear on an enigmatic, controlled, supremely rational character. In this adaptation of the 1927 novel Thérèse Desqueyroux by the subsequently Nobel Prize-winning François Mauriac, Thérèse is very far from an old-fashioned lady of literature. She enters into marriage with the practical and uncharismatic Bernard (Gilles Lellouche); their families own vast swaths of adjoining pine forests, and their union will create a profitable dynasty. Poker-faced Thérèse seems all right with this, although she becomes troubled by news that Bernard’s sister (Anaïs Demoustier)—her lifelong bestie—has launched a torrid affair with a callow-yet-hunky young man. This is a prelude to the section that occupies much of the film, as Thérèse ponders the exact dosage of her husband’s anemia medicine, which contains arsenic. He trusts her to keep track of how much he’s ingested, and she begins to measure her future in spoonfuls of the stuff.